The increased level of hemoglobin in the bone marrow of mice, appearing after irradiation, is reverted by 19S alpha-2 globulin towards the normal level. The optimal conditions for this effect were found to be similar to those which produce stimulation of the regeneration of the thymus in irradiated mice. Injection of syngeneic bone marrow cells into irradiated mice produces a similar reversal of the increased level of hemoglobin in mice. A possible correlation between this effect of 19S alpha-2 globulin and its ability to regenerate irradiation damage in the bone marrow and thymus of mice is discussed.

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