The evolution, time course and dose dependence of the moist reaction occurring following increasing exposures of x-rays are summarized. Histologic and kinetic parameters of nonirradiated skin are reviewed. These data and known radiobiologic principles are used to construct a simple model to explain the effects of irradiation on the skin. The observed and predicted results are compared and several discrepancies are noted. The main ones were that the field was not uniformly involved and the time of healing was neither dose dependent nor time dependent. The significance of these findings are discussed. Possible modifications of the model are suggested and areas of future study are outlined.

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