Interstitial-cell (Leydig) tumors of the testes were found in rats 2 years after they had been subjected to localized testicular irradiation. While only one neoplasm appeared in 45 nonirradiated control rats, 6 of 62 rats irradiated with 150 R, and 40 of 74 rats irradiated with 500 R had interstitial-cell neoplasms. All the neoplasms were benign and confined to the testes, and none metastasized. Apparently these neoplasms developed from hyper-plastic interstitial cells, and gonadotropin stimulation is suggested as a promoting factor in their pathogenesis.
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Research Article| November 01 1969
Leydig-Cell Tumors in Rat Testes Subjected to Low-Dose X-Irradiation
Stuart Lindsay ;
Clarence W. Nichols,, Jr. ;
Glenn E. Sheline ;
Radiat Res (1969) 40 (2): 366–378.
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Stuart Lindsay, Clarence W. Nichols,, Glenn E. Sheline, I. L. Chaikoff; Leydig-Cell Tumors in Rat Testes Subjected to Low-Dose X-Irradiation. Radiat Res 1 November 1969; 40 (2): 366–378. doi: https://doi.org/10.2307/3572825
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