Radioprotective Effect of Sodium Fluoroacetate in Mice

A quantitative study of the radioprotective effect of sodium fluoroacetate (FAc) in white mice of H-strain, 9-12 weeks old was made. The results of the experiments show that FAc administered intraperitoneally 3 hours before irradiation in the amount of 7.5 mg/kg increases the average${\rm LD}_{50(30)}$ value from 648 R (controls) to 998 R (protected). A comparison of the obtained results with data on the radioprotective effect of cysteine, cysteamine, AET, serotonin and hypoxia indicates that the radioprotective effect of FAc is not statistically different from the effect of these compounds. The protective effect of FAc, however, requires much smaller doses (50-75 μmoles/kg). At the same time the duration of protection after FAc administration is much longer, lasting roughly from 30 minutes to 7 hours after the application of the substance, with maximum protection between the first and second hour.