A single I. P. injection of evaporated bovine milk or sodium caseinate into mice immediately after a whole body exposure to 600 R of x-rays increased the 30-day survival from 45 to 73 and 80%, respectively. These substances also doubled the mitotic activity of bone marrow in nonirradiated and irradiated (300 R) mice within 6 hours of injection. In contrast, a single intraperitoneal injection of calcium caseinate and bovine parathyroid extract (given subcutaneously) were without effect on either the mitotic activity of bone marrow or the level of radiation mortality. The bovine parathyroid hormone did not affect the levels of the total or free calcium in the blood, while milk and calcium caseinate increased the total calcium concentration, but did not affect the concentration of physiologically active free calcium. Sodium caseinate, on the other hand, transiently lowered the levels of both the total and the free calcium. Evidence is presented which suggests that a hypocalcemia-induced release of endogenous parathyroid hormone is responsible for the mitogenic and therapeutic activities of sodium caseinate. The mechanism of action of milk is not known. The mitogenic and therapeutic actions of milk and sodium caseinate support the concept that the postirradiation stimulation of cell proliferation in hematopoietic tissues can play an important role in reducing radiation lethality.
Skip Nav Destination
Research Article| December 01 1969
The Relation between the Mitogenic and Therapeutic Actions of Milk and Sodium Caseinate in X-Irradiated Mice
Radiat Res (1969) 40 (3): 601–612.
- Views Icon Views
- Share Icon Share
- Search Site
R. H. Rixon, J. F. Whitfield; The Relation between the Mitogenic and Therapeutic Actions of Milk and Sodium Caseinate in X-Irradiated Mice. Radiat Res 1 December 1969; 40 (3): 601–612. doi: https://doi.org/10.2307/3573013
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner