Twenty-four germfree and sixteen conventional mice of the ND-2 strain were given 700 rads whole-body irradiation and the pattern of radiation induced bone marrow damage was studied. The decrease in bone marrow cellularity was found to be similar in both groups. By day four to five after exposure the bone marrow became nearly aplastic, and consequently the blood cell counts reached very low levels. From data presented it seems unlikely that the germfree state affects cell proliferation in any of the hemopoietic systems, as has been described for the gut epithelium. Possible explanations for the prolonged postirradiation survival time of germfree compared to conventional mice are discussed.

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