Rats given single x-ray doses to the whole body or whole-body with temporarily exteriorized kidneys shielded (300 R or 500 R) or to the temporarily exteriorized kidneys only (300 R, 500 R or 1000 R), together with their surgical and nonsurgical sham-irradiated control rats, were studied periodically for 17 months or longer postexposure for systolic blood pressure and renal histopathology. Increased systolic blood pressure, above the time-dependent increases in nonirradiated animals, was induced by all doses and modes of irradiation; the increases were dose-dependent and time-dependent, but independent of the mode of irradiation at given dose levels. Progressive arteriolonephrosclerosis, greater in degree at given times than that in nonirradiated animals, was induced by all doses and modes of irradiation in dose-dependent fashion. Nephrosclerosis progressed more rapidly in animals whose kidneys were irradiated, less rapidly in those whose kidneys were shielded during irradiation, and least rapidly in nonirradiated animals. The initiation of blood pressure increase by renal irradiation required little renal damage, and this was apparently limited to subtle degenerative and occlusive changes in fine vasculature, especially cortical arterioles. Much of the progressive nephrosclerotic process developed after the rise of blood pressure, apparently partly as a result of the hypertension.
Skip Nav Destination
Research Article| January 01 1970
Radiation Hypertension and Nephrosclerosis
Radiat Res (1970) 41 (1): 39–56.
- Views Icon Views
- Share Icon Share
- Search Site
Bruce W. Wachholz, George W. Casarett; Radiation Hypertension and Nephrosclerosis. Radiat Res 1 January 1970; 41 (1): 39–56. doi: https://doi.org/10.2307/3572894
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner