The bone marrow-derived precursors of macrophages and monocytes in inflammatory peritoneal exudates in the mouse are radiosensitive and vinblastine-sensitive cells. The degree of sensitivity to these two agents is comparable to that reported for other hematopoietic progenitor cells and for cells mediating various parameters of the immune response; this is in contrast to the known radio- and drug-resistance of the mature macrophage. The rate and timing of recovery of these macrophage precursors after 80 μg vinblastine is similar to the patterns of recovery of erythropoietin-sensitive cells after the drug.
Effects of Ionizing Radiation and Vinblastine on the Proliferation of Peritoneal Macrophage Precursors in the Mouse
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Michael G. Chen, John C. Schooley; Effects of Ionizing Radiation and Vinblastine on the Proliferation of Peritoneal Macrophage Precursors in the Mouse. Radiat Res 1 March 1970; 41 (3): 623–636. doi: https://doi.org/10.2307/3572849
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