Telogen mouse hairs treated with single doses of 2000 to 2500 rads showed persistent impairment of postirradiation growth as measured by determinations of overall hair length. Reductions in length of surviving hairs, compared to contralateral controls, averaged 27% for the hairs newly grown postirradiation. Subsequent hair generations showed no significant recovery: reductions in length of hairs from the same treatment sites averaged 33% 10 months after irradiation. Cyclic regrowth of hair in these areas was also unusually slow: after plucking, hair density was not fully restored in irradiated areas for 4 weeks or longer in contrast to the normal replacement time of 2 1/2 weeks observed in plucked control sites. This change was demonstrable up to 14 months postirradiation. Exposure of telogen hairs to a somewhat smaller dose of 1500 rads resulted in a 12% reduction of length in the generation of hairs growing immediately postirradiation, followed by complete recovery in the subsequent cycle of hair growth. The persistence of effects in the animals subjected to high doses of radiation may be the result of overall reduction in stem cell pool size since investigations with tritiated thymidine showed that cell generation cycles were almost identical in treatment and control sites but that the mitotic index was substantially reduced in the irradiated areas.
Skip Nav Destination
Research Article| July 01 1970
Persistent Impairment of Hair Growth after Single Large Doses of X-Rays
Frederick D. Malkinson ;
Malvin L. Griem ;
Radiat Res (1970) 43 (1): 83–91.
- Views Icon Views
- Share Icon Share
- Search Site
Frederick D. Malkinson, Malvin L. Griem, Ruzica Marianovic; Persistent Impairment of Hair Growth after Single Large Doses of X-Rays. Radiat Res 1 July 1970; 43 (1): 83–91. doi: https://doi.org/10.2307/3572860
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr