The data presented led to the following conclusions: (1) there is significant incorporation of tritiated thymidine into all tissues of the mouse after oral ingestion; (2) at least part of this incorporation is not related to mitotic activity; (3) intraperitoneal injection produces greater nonvolatile tissue activities in proliferative tissues than oral ingestion; (4) a radiation effect is produced by levels of tritium activity which deliver a radiation dose to the nucleus that is not greater than 15 rads; and (5) assuming that metabolism is comparable to that in the mouse, a single oral ingestion of 1.0 mCi or less of tritiated thymidine by man would be required to deliver a radiation dose of 1.25 rads over a period of 13 weeks to the nuclei of a significant fraction of cells in the total body.

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