P-388 murine leukemia cells were irradiated in vitro under aerobic or hypoxic conditions with monoenergetic track-segments of beams of accelerated deuterons or alpha particles at ionization densities (LETs) of 6-86 ke V/μm of unit density absorber, and the survival of their reproductive capacity was assayed in vivo. No significant protection was conferred by hypoxia at the highest LET studied, in contrast to the only similar published studies using human-derived T-1 cells in which significant hypoxic protection was observed up to LETs of 140-165 ke V/μm. Similar differences between the response of murine P-388 cells and human T-1 cells to fast neutrons of different energies are discussed.

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