Dose reduction factors (DRF) were determined for various doses of mercaptoethylamine (MEA) administered either intravenously or intraperitoneally to mice before whole body x-irradiation. MEA doses ranging from 125 to 600 mg/kg were administered intravenously while MEA doses as high as 750 and 900 mg/kg were administered intraperitoneally. The toxicity of MEA was greater in mice kept at 30°C than in those kept at 22°C. The detoxification rate for MEA was about 90 mg/kg/hour. Pentobarbital administration, either in a single or in multiple injections, after irradiation and control of environmental temperature were used to counteract the toxicity following high doses of MEA. The acute mortality rate after large doses of MEA was high. The DRF values were approximately proportional to the MEA dose up to 600 mg/kg. The highest DRF (2.81) was obtained with an intravenous MEA dose of 600 mg/kg.
Skip Nav Destination
Research Article| December 01 1970
Dose Reduction Factor for Radiation Lethality in Mice as a Function of the Dose of Mercaptoethylamine
Radiat Res (1970) 44 (3): 738–747.
- Views Icon Views
- Share Icon Share
- Search Site
A. T. Hasegawa, H. D. Landahl; Dose Reduction Factor for Radiation Lethality in Mice as a Function of the Dose of Mercaptoethylamine. Radiat Res 1 December 1970; 44 (3): 738–747. doi: https://doi.org/10.2307/3573153
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development
Ziad Francis, Sebastien Incerti, Sara A. Zein, Nathanael Lampe, Carlos A. Guzman, Marco Durante
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
RITCARD: Radiation-Induced Tracks, Chromosome Aberrations, Repair and Damage
Ianik Plante, Artem Ponomarev, Zarana Patel, Tony Slaba, Megumi Hada