It has been reported previously (1) that plasma of rats made leukopenic by irradiation could, upon injection into a normal rat, elicit a peripheral leukocytosis which is due, at least in part, to the release of large numbers of neutrophils from the bone marrow. In the present experiment, utilizing the radiation protective technique of postirradiation parabiosis, it was investigated whether the unirradiated partner of an irradiated parabiont would manifest any changes in the stem cell compartment of its bone marrow, i.e., colony-forming units (CFU) as a result of its union to an irradiated partner. The pattern of hematopoietic recovery in the irradiated parabiont as measured by total femoral cellularity and CFU content was also investigated. Results indicated that in the unirradiated partner of an irradiated (leukopenic) parabiont the CFU increase to 3.5 times their original number; only part of this increase is attributed to the phenomenon of parabiosis itself. After an early fall in bone marrow cellularity and CFU concentration, the irradiated parabiont begins to recover both cellularity and CFU content, the latter, however, shows fluctuations which are discussed. A general scheme is proposed for the mechanism of postirradiation protection against the hematopoietic form of radiation death.
Skip Nav Destination
- Views Icon Views
- Share Icon Share
- Search Site
Marvin Sodicoff; Colony-Forming Units in Rat Parabionts. Radiat Res 1 December 1970; 44 (3): 758–770. doi: https://doi.org/10.2307/3573155
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr