Chinese hamster cells were synchronized with hydroxyurea and then stored at room temperature. These G1/ S cells, were uniform in sensitivity, did not progress through the cell cycle at room temperature, and their response to a single acute exposure of x-rays remained constant for at least 24 hours of room temperature storage. These cells were used to investigate the repair of sublethal damage under aerated and hypoxic conditions. Under aerated conditions a recovery factor of 3 was observed; under conditions of extreme hypoxia, defined by the presence of less than 16 parts per million of oxygen in the gas phase, repair of sublethal damage appeared to be completely inhibited.

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