Glutathionesulfonic acid is identified as the sole product of exposure of dilute, air-saturated aqueous solutions of the hexapeptide disulfide oxidized glutathione to doses of X-rays sufficient to destroy up to 80% of the starting material. The radiation-chemical yields are similar to those of cysteic acid from cystine and taurine from cystamine under similar conditions and exhibit concentration dependence similar to that shown by these simpler disulfides. Qualitative interpretation of the results is consistent with the proposal that the initiating step is electron abstraction from the disulfide giving a cation-radical.

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