An equation has been derived that predicts surviving fraction when cells which have been equilibrated with oxygen are exposed to high intensity single pulses of radiation. The equation allows for the quantitative examination of various features of pulse irradiated survival curves. It is found that the spacing between anoxic segments of the survival curves is not a linear function of initial oxygen concentration. A function is added to the equation thereby permitting a fit of the derived equation to experimentally determined survival curves where a shoulder is involved. Fitting the equation to experimental data provides a means for determining the dose required to deplete oxygen in the cells and for determining the constant K in the equation that relates radiosensitivity to oxygen concentration. As a result of the derivation, an experiment at conventional dose rates is suggested.
Skip Nav Destination
Research Article| May 01 1972
- Views Icon Views
- Share Icon Share
- Search Site
Herbert Weiss; An Equation for Predicting the Surviving Fraction of Cells Irradiated with Single Pulses Delivered at Ultra-High Dose Rates. Radiat Res 1 May 1972; 50 (2): 441–452. doi: https://doi.org/10.2307/3573501
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner