Hematological studies and measurements of plasma iron concentration, plasma copper concentration, total iron-binding capacity, and total plasma protein were carried out in eight control sheep and eight sheep which received 25,000 rads of beta radiation to the skin. Thrombocytosis began at approximately 4 weeks postirradiation and persisted to approximately 18 weeks postirradiation. Lymphocytes and basophils in the irradiated sheep were significantly lower than in the control sheep, while neutrophils and eosinophils were elevated beginning at approximately 8 weeks postirradiation. Mean corpuscular volume decreased and total red cell count increased in the irradiated sheep. Two periods of hypoferremia occurred in the irradiated sheep: one from 2-3 weeks and the other from 8-16 weeks postirradiation. Plasma copper concentration, total iron-binding capacity, and total plasma protein were significantly elevated in the irradiated sheep.

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