Liver tumors were induced in mice by neutron irradition followed by a dose of CCl4. The relation between tumor induction and neutron dose was found to be linear at low doses. This is interpreted to mean that although the tumor-induction process requires two or more independent events, only one of these can be considered a mutation. This result may or may not be applicable to other tumor systems.
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Research Article| June 01 1972
The Role of Mutations in Liver Tumor Induction in Mice
Radiat Res (1972) 50 (3): 539–542.
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Howard J. Curtis, John Tilley; The Role of Mutations in Liver Tumor Induction in Mice. Radiat Res 1 June 1972; 50 (3): 539–542. doi: https://doi.org/10.2307/3573551
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