The present investigation was carried out to determine if thymocyte radiation injury leading to interphase death is repaired in vivo. For this purpose either thymus DNA (an index of cell number) or thymus cell number were measured following single and fractionated whole-body x-irradiation. Three days after single exposures, thymus DNA decrease was determined to be dose dependent within the range of 0-175 R. The principal mechanism for this rapid decrease in DNA has previously been shown to be due to interphase death. Two 75-R exposures separated by 4 hours reduced the number of thymus cells and thymus DNA to the same extent as a single 150-R exposure. Additional experiments showed no differences in DNA content of the gland with intervals between exposures of 2 and 7 hours. Fractionation intervals of 10, 15, and 20 hours resulted in increased DNA as compared to single exposure. Measurement of the mitotic index in the thymus as a function of time after a single exposure of 75 R suggests that increased DNA in the gland after fractionation intervals greater than 7 hours is the result of cell division completed between fractions. Therefore, the method cannot be used to study recovery when fractionation intervals exceed 7 hours. Within this limitation the study shows no detectable recovery of radiation injury leading to interphase death in vivo.
Skip Nav Destination
Close
Article navigation
1 August 1972
Research Article|
August 01 1972
Irreparable Interphase Injury Produced by X-Irradiation of the Rat Thymus in Vivo
Radiat Res (1972) 51 (2): 391–401.
Citation
K. L. Jackson, G. M. Christensen; Irreparable Interphase Injury Produced by X-Irradiation of the Rat Thymus in Vivo. Radiat Res 1 August 1972; 51 (2): 391–401. doi: https://doi.org/10.2307/3573618
Download citation file:
Close
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr