Previous work has shown irradiation on day 11 of gestation in the rat produces high frequencies of eye anomalies. An exposure-response curve established for the young of irradiated females revealed minimal eye damage at 50 R and near maximal damage at 150 and 200 R total exposure. An exposure of 100 R gave responses which involved only eye anomalies and therefore was chosen for a comprehensive exposure-rate study. Exposure rates of 0, 1, 2, 3.3, 5, 10, 25, and 47 R/min were used. Results revealed a rapid increase in eye damage up to 3.3 R/min with gradual, but not significant further increases at 5 and 10 R/min. Exposure rates of 25 and 47 R/min showed significantly fewer defects than the 3.3, 5, and 10 R group complex.
Exposure-Rate Response in the Prenatally Irradiated Rat: Effects of 100 R on Day 11 of Gestation to the Developing Eye
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John R. Strange, R. L. Murphree; Exposure-Rate Response in the Prenatally Irradiated Rat: Effects of 100 R on Day 11 of Gestation to the Developing Eye. Radiat Res 1 September 1972; 51 (3): 674–684. doi: https://doi.org/10.2307/3573634
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