Mice were exposed to 1500-R x-radiation and injected with horseradish peroxidase 2 minutes prior to sacrifice on days 1, 2, 3, 3.5, and 4 postexposure. Kidney damage in the form of increased tubular permeability to peroxidase was detected as early as day 1, suggesting that functional damage occurred before morphologic lesions became apparent. Changes were observed in glomeruli on day 2, mainly involving capillary endothelium and some focal thickening of the basement membrane.

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