Osteosarcomas which arose in CBA mice following the administration of 0.7 μCi${}^{90}{\rm Sr}/{\rm g}$ body wt were tested for the ability to induce resistance to their own transplantation in recipient mice, syngeneic with the strain of origin. The recipients were pretreated by repeated injections of heavily irradiated cells derived from the tumors and/or were preirradiated on the whole body with 400 R. Controls included untreated recipients and recipients pretreated with heavily irradiated cells from normal, syngeneic tissues. Graded doses of viable tumor cells between 5 × 10 and 105 were used for the transplantation challenge. A total of 23 different osteosarcomas were tested in corresponding groups, the total number of challenge amounting to 1637. The incidence of progressively growing tumors was registered for a period of 8-12 months after transplantation. Insignificant differences in the tumor incidence were found between the groups pretreated with irradiated neoplastic or normal tissues and the untreated controls. In the whole body-irradiated mice the incidence was significantly greater than in the unirradiated ones. Treatment with heavily irradiated tumor cells prior to whole body irradiation decreased the frequency of progressively growing tumors in comparison to treatment with heavily irradiated normal tissues. In all preirradiated groups, osteosarcomas with fibroblastic character developed in somewhat greater frequency than osteosarcomas with osteoblastic character. The data were interpreted as indicating that radiostrontium-induced osteosarcomas possess specific transplantation antigens. The degree of the antigenicity of the tumors may be related to their histologic type.

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