Growth curves for Chinese hamster fibroblasts are determined for various partial pressures of oxygen. It is found that for oxygen tensions greater than 500 parts per million, growth is only minimally affected. At less than 500 parts per million, the number of cells increases exponentially for only a limited time and then remains constant. Viability, as determined by colony forming ability, remains high during this plateau phase even after 4 days under extremely hypoxic conditions.
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Research Article| January 01 1973
The Effect of Hypoxia on the Generation Time of Mammalian Cells
Radiat Res (1973) 53 (1): 43–48.
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C. J. Koch, J. Kruuv, H. E. Frey; The Effect of Hypoxia on the Generation Time of Mammalian Cells. Radiat Res 1 January 1973; 53 (1): 43–48. doi: https://doi.org/10.2307/3573446
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