The mobilization of internally-deposited241 Am by single doses of CaDTPA and ZnDTPA as dependent on time and dosage was studied. Notwithstanding the kind of chelate, their effect in the organs is sustained over several days and diminishes with increasing time interval between injection of241 Am and chelate. The removal of241 Am from the liver is markedly higher than from other organs. With early treatment, i.e., ≤24 hours after241 Am injection, CaDTPA is slightly more effective than ZnDTPA, whereas there is no difference in efficacy in the case of delayed administration. The theoretical and practical implications of the results are discussed.
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A. Seidel; Comparison of the Effectiveness of CaDTPA and ZnDTPA in Removing241 Am from the Rat. Radiat Res 1 May 1973; 54 (2): 304–315. doi: https://doi.org/10.2307/3573708
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