Dithiothreitol has been used in model experiments to investigate its free radical reactivity in relation to its properties as a radioprotector. Absolute rate constants for the reaction of this sulfydryl compound with hydroxyl radicals and secondary inorganic radical anions have been determined using the technique of pulse radiolysis. The repair of several organic free radicals by their reaction with dithiothreitol has also been demonstrated. Transient absorption spectra observed after reaction of these radicals with this -SH compound have been measured.

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