Thrombocyte-rich plasma, prepared from isogenic unirradiated mice, was intravenously transfused to irradiated mice every day during days 5-9 or 12 after irradiation. Thrombocyte-rich plasma administered after x-irradiation showed beneficial effects on survival of mice: 30 day survival increased from 42 to 100% at 708 rads, from 0 to 90% at 755 rads, and from 0 to 26% at 850 rads. No therapeutic effects were observed, however, after injection of streptomycin and penicillin, blood plasma, or thrombocyte-poor plasma which contained an equal number of erythrocytes and a higher number of leukocytes as in thrombocyte-rich plasma. There were no detectable colony-forming cells in the thrombocyte-rich plasma.
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Wataru Nakamura; Effect of Thrombocyte-Rich Plasma on X-Ray Induced Bone Marrow Death in Mice. Radiat Res 1 July 1973; 55 (1): 118–128. doi: https://doi.org/10.2307/3573817
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