Diploid cultures of Saccharomyces cerevisiae carrying mutant alleles of the gene rad 1 show a range of sensitivities to 254-nm ultraviolet light and vary in their responses to post-uv liquid-holding treatment. The mutant cultures containing alleles conferring the lowest sensitivity to uv are dominant to the cultures containing alleles conferring maximum sensitivity and cultures carrying such alleles all show liquid-holding recovery. In contrast, in diploids containing only alleles conferring maximum sensitivity, no changes in viability are produced by liquid-holding treatment. The results indicate that the rad 1 gene is involved in the excision repair of uv-induced pyrimidine dimers and that the integrity of the rad 1 gene is a necessary requirement for liquid-holding recovery.

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