The sensitivity of heat-synchronized Tetrahymena pyriformis to x-radiation was dependent upon the magnitude of the radiation dose and the age of the cell population. Division delays of increasing duration were exhibited by cells irradiated with progressively greater doses of x-radiation at a specific time during the cell cycle. Moreover, division delays of increasing duration were produced when cells were irradiated with a specific dose at progressively later times during the cell cycle. The precise time of transition from radiation sensitivity to radiation insensitivity was found to be dose dependent. Studies involving the addition of either actinomycin D or puromycin to cells at various times after irradiation indicated that both RNA and protein synthesis were required for the recovery of Tetrahymena from the radiation effects; cell division was employed as an index for recovery from radiation damage. DNA, RNA, and protein synthesis in irradiated cells were all differentially depressed. These results are discussed in terms of their relationship to the radiation-induced delay of cell division.
Skip Nav Destination
Research Article| September 01 1973
Macromolecular Synthesis and Cell Division in X-Irradiated Tetrahymena
Radiat Res (1973) 55 (3): 411–421.
- Views Icon Views
- Share Icon Share
- Search Site
Izhak J. Paul, Arthur M. Zimmerman; Macromolecular Synthesis and Cell Division in X-Irradiated Tetrahymena. Radiat Res 1 September 1973; 55 (3): 411–421. doi: https://doi.org/10.2307/3573846
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development
Ziad Francis, Sebastien Incerti, Sara A. Zein, Nathanael Lampe, Carlos A. Guzman, Marco Durante
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
RITCARD: Radiation-Induced Tracks, Chromosome Aberrations, Repair and Damage
Ianik Plante, Artem Ponomarev, Zarana Patel, Tony Slaba, Megumi Hada