The secretion of <tex-math>${}^{85}{\rm Sr}$</tex-math> and <tex-math>${}^{47}{\rm Ca}$</tex-math> from the vascular space into the intestine was determined in rats as a function of time during both feeding and fasting. <tex-math>${}^{85}{\rm Sr}$</tex-math> and <tex-math>${}^{47}{\rm Ca}$</tex-math> were injected intravenously, and the rats were sacrificed after 1/2, 1, 2, 4, and 24 hours. The gastrointestinal radioisotope content was measured in six separate segments. During feeding, slightly more <tex-math>${}^{47}{\rm Ca}$</tex-math> than <tex-math>${}^{85}{\rm Sr}$</tex-math>, 5.1% vs 4.6% of the dose, respectively, was present at 1/2 hour in the gastrointestinal tract. At 4 hours the <tex-math>${}^{85}{\rm Sr}$</tex-math> in the intestine rose to 7.0%, while <tex-math>${}^{47}{\rm Ca}$</tex-math> had increased only very slightly. Between 4 and 24 hours the excretion of both isotopes via the intestine increased, but the increase in <tex-math>${}^{85}{\rm Sr}$</tex-math> excretion was greater than that of <tex-math>${}^{47}{\rm Ca}$</tex-math>, the values being 11% and 8.6% of the dose at 24 hours, respectively. Fasting decreased the secretion of both isotopes into the intestine at all time intervals, and this effect was more marked for <tex-math>${}^{47}{\rm Ca}$</tex-math> than for <tex-math>${}^{85}{\rm Sr}$</tex-math>. At 24 hours, during fasting, the intestinal excretion of <tex-math>${}^{85}{\rm Sr}$</tex-math> was less than half of the feeding level, while the intestinal excretion of <tex-math>${}^{47}{\rm Ca}$</tex-math> was less than one-third of that during feeding, resulting in a <tex-math>${}^{85}{\rm Sr}/{}^{47}{\rm Ca}$</tex-math> ratio of 2.0 during fasting vs 1.3 during feeding.

Skip Nav Destination

Close

Article navigation

1 October 1973

Research Article|
October 01 1973

# Passage of <tex-math>${}^{85}{\rm Sr}$</tex-math> and <tex-math>${}^{47}{\rm Ca}$</tex-math> into the Gastrointestinal Tract in Rats during Feeding and Fasting

*Radiat Res*(1973) 56 (1): 110–121.

Citation

Janet M. Warren, Herta Spencer; Passage of <tex-math>${}^{85}{\rm Sr}$</tex-math> and <tex-math>${}^{47}{\rm Ca}$</tex-math> into the Gastrointestinal Tract in Rats during Feeding and Fasting. * Radiat Res* 1 October 1973; 56 (1): 110–121. doi: https://doi.org/10.2307/3573795

Download citation file:

Close

## Sign in

Don't already have an account? Register

### Client Account

You could not be signed in. Please check your email address / username and password and try again.

### Sign in via your Institution

Sign in via your Institution### Citing articles via

Commonalities Between COVID-19 and Radiation Injury

Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo

Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?

Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held

Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light

Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner