Repair replication was measured after uv-irradiation of WI-38 cells at different passage numbers. A reduced level of DNA synthesis was found only at the last passage before cessation of cell division. This reduction was not evident two passages before this and we conclude that excision repair deficiency is not the basis for in vitro aging of diploid human cells.

This content is only available as a PDF.
You do not currently have access to this content.