Repair replication was measured after uv-irradiation of WI-38 cells at different passage numbers. A reduced level of DNA synthesis was found only at the last passage before cessation of cell division. This reduction was not evident two passages before this and we conclude that excision repair deficiency is not the basis for in vitro aging of diploid human cells.
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Research Article| December 01 1973
Ultraviolet-Induced Repair Replication in Aging Diploid Human Cells (WI-38)
Robert B. Painter ;
Judith M. Clarkson ;
Radiat Res (1973) 56 (3): 560–564.
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Robert B. Painter, Judith M. Clarkson, Barbara R. Young; Ultraviolet-Induced Repair Replication in Aging Diploid Human Cells (WI-38). Radiat Res 1 December 1973; 56 (3): 560–564. doi: https://doi.org/10.2307/3573725
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