The effects of single-dose whole-body and partial-body irradiation and of continuous irradiation on haptoglobin levels in plasma were evaluated in C57BL/6J mice. The haptoglobin levels reached a maximum at 24 hr after a single whole-body exposure and increased with increases in the radiation dose. After irradiation with 600 R there was a secondary increase at 6-7 days. Syngeneic bone marrow cell treatment appeared to enhance the recovery process from the secondary increase. In the case of partial-body irradiation, the increase of haptoglobin was not necessarily correlated with the volume dose of the irradiated parts of the body. Continuous irradiation from137 Cs for 32 weeks at daily doses of 24 R did not have any influence on haptoglobin levels. These results indicate that the haptoglobin levels shortly after an acute irradiation reflect a tissue injury which is not evoked by low dose-rate irradiation, and that the lethal radiation provides a different factor which evokes a secondary increase of haptoglobin.

This content is only available as a PDF.
You do not currently have access to this content.