The effects of single-dose whole-body and partial-body irradiation and of continuous irradiation on haptoglobin levels in plasma were evaluated in C57BL/6J mice. The haptoglobin levels reached a maximum at 24 hr after a single whole-body exposure and increased with increases in the radiation dose. After irradiation with 600 R there was a secondary increase at 6-7 days. Syngeneic bone marrow cell treatment appeared to enhance the recovery process from the secondary increase. In the case of partial-body irradiation, the increase of haptoglobin was not necessarily correlated with the volume dose of the irradiated parts of the body. Continuous irradiation from137 Cs for 32 weeks at daily doses of 24 R did not have any influence on haptoglobin levels. These results indicate that the haptoglobin levels shortly after an acute irradiation reflect a tissue injury which is not evoked by low dose-rate irradiation, and that the lethal radiation provides a different factor which evokes a secondary increase of haptoglobin.
Skip Nav Destination
Research Article| February 01 1974
Haptoglobin Levels in Plasma of Irradiated Mice
Radiat Res (1974) 57 (2): 239–245.
- Views Icon Views
- Share Icon Share
- Search Site
Jun-ichiro Hayakawa, Takehiko Tsuchiya; Haptoglobin Levels in Plasma of Irradiated Mice. Radiat Res 1 February 1974; 57 (2): 239–245. doi: https://doi.org/10.2307/3573830
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner