Changes in proliferative response to three successive administrations 48 hr apart of isoproterenol were studied in the parotid gland of the mouse previously given local x-irradiation. X-Irradiation produced dose-dependent inhibition of DNA synthesis and cell proliferation induced by the drug. A D0 of approximately 900 R was obtained from the dose-response curve constructed on the basis of changes in the DNA content of the organ at the end of the mitotic stimulations. Similarly, split-dose experiments showed a slight but significant recovery from the radiation damage within a few hours after irradiation. However, complete recovery in the capability of undergoing DNA synthesis and cell proliferation on isoproterenol stimulation took much longer.

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