Changes in proliferative response to three successive administrations 48 hr apart of isoproterenol were studied in the parotid gland of the mouse previously given local x-irradiation. X-Irradiation produced dose-dependent inhibition of DNA synthesis and cell proliferation induced by the drug. A D0 of approximately 900 R was obtained from the dose-response curve constructed on the basis of changes in the DNA content of the organ at the end of the mitotic stimulations. Similarly, split-dose experiments showed a slight but significant recovery from the radiation damage within a few hours after irradiation. However, complete recovery in the capability of undergoing DNA synthesis and cell proliferation on isoproterenol stimulation took much longer.
Effects of X-Irradiation on Cell Proliferation and DNA Synthesis Induced by Administration of Isoproterenol in Salivary Glands of the Mouse
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I. Furuno, T. Iwasaki, H. Matsudaira; Effects of X-Irradiation on Cell Proliferation and DNA Synthesis Induced by Administration of Isoproterenol in Salivary Glands of the Mouse. Radiat Res 1 March 1974; 57 (3): 431–441. doi: https://doi.org/10.2307/3573890
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