Sprague-Dawley adult male rats were exposed to incapacitating doses of mixed gamma-neutron radiation in a single pulse from the AFRRI-TRIGA reactor. The activities of the enzymes choline acetyltransferase (ChAc), acetylcholinesterase (AChE), monoamine oxidase (MAO) and RNA polymerase (RNAp) were determined in the cerebral cortex, cerebellum and hippocampus. It was found that as early as 4 min after irradiation of the animal the activity of MAO was markedly decreased in all 3 brain areas investigated. ChAc and RNAp activities were also decreased but to a lesser extent. No appreciable changes in the activity of AChE were observed.

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