Repeated X-irradiation (4 × 450 rads) of mice produces a decreased rate of bone marrow regeneration to a suboptimal level, compared to that after a single dose of 450 rads. 14 MeV neutrons are more effective in producing this reduced level by a factor of 1.7-1.8. The irradiated host (single 850 rads or 4 × 450 rads X-rays) is responsible for a lower growth rate of colony-forming units. The suboptimal plateau however is a "cellular effect," and these are additive during endogenous repopulation. A host effect is not demonstrable in terms of changes in the colony-stimulating activity of the femur shaft in bone marrow cultures.
Skip Nav Destination
Research Article| September 01 1974
Effect of Repeated Doses of X-Rays or 14 MeV Neutrons on Mouse Bone Marrow
J. H. Hendry ;
Radiat Res (1974) 59 (3): 645–652.
- Views Icon Views
- Share Icon Share
- Search Site
J. H. Hendry, N. G. Testa, L. G. Lajtha; Effect of Repeated Doses of X-Rays or 14 MeV Neutrons on Mouse Bone Marrow. Radiat Res 1 September 1974; 59 (3): 645–652. doi: https://doi.org/10.2307/3574081
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner