The inhibitory as well as stimulatory effects of irradiation on protein metabolism are preserved during storage of rat skin. Upon incubation of the tissue after storage, these effects can be evaluated. A single initial irradiation of 1500 R and 3000 R affects the free amino acid concentrations in the tissue and their release into the storage medium, as a result of an increased cellular destruction and protein degradation. A lower dose of 750 R reduces the amino acid release, possibly as a result of a stimulatory effect on protein synthesis. In vitro irradiation of skin results in a stimulatory effect on the incorporation of <tex-math>$[2\text{-}{}^{14}{\rm C}]$</tex-math> glycine into the proteins after subsequent incubation.

This content is only available as a PDF.
You do not currently have access to this content.