High-fired <tex-math>${}^{239}\text{plutonium}$</tex-math> oxide particles injected into the hind paws of beagles accumulated in the popliteal lymph nodes. Histopathologic changes in these lymph nodes were characterized primarily by reticular cell hyperplasia, increased numbers of macrophages, necrosis, and fibroplasia. Eventually the plutonium particles became sequestered by scar tissue that often replaced the normal architecture of the lymph node. Light-microscopic autoradiographs of the popliteal lymph nodes showed a time-related increase in number of alpha tracks per plutonium source. Electron microscopy showed that plutonium particles were aggregated in phagolysosomes of macrophages.

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