Skin from beagles bearing241 Am with and without tumors and from controls was studied. The metabolism of$[4\text{-}{}^{14}{\rm C}]\text{cortisol}$ was significantly elevated over controls in both${}^{241}{\rm Am}\text{-injected}$ groups. This metabolic alteration may indicate a radiation-induced change in cortisol metabolism by skin from${}^{241}{\rm Am}\text{-injected}$ beagles.

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