Intracellular cyclic AMP was found to be significantly elevated in V-79 cells by addition to the culture medium of Prostaglandin E1, or of compounds inhibiting cyclic AMP phosphodiesterase. Cells in which elevated cyclic AMP had been induced by these means showed modified survival after X-irradiation. For high cyclic AMP cells the extent of the shoulder on the survival curve was increased while the exponential slope of the curve was decreased. Thus, more high cyclic AMP cells survive low doses of radiation than do control cells, but with increasing dose the high cyclic AMP cells become progressively more radiosensitive compared with controls. The increased size of the shoulder on the survival curve for high cyclic AMP cells is not correlated with an increased capacity to repair sublethal damage in these cells.
Skip Nav Destination
- Views Icon Views
- Share Icon Share
- Search Site
Shirley Lehnert; Modification of Postirradiation Survival of Mammalian Cells by Intracellular Cyclic AMP. Radiat Res 1 April 1975; 62 (1): 107–116. doi: https://doi.org/10.2307/3574188
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr