A highly polymeric preparation of plutonium-239 was injected intravenously into five groups of beagle dogs. An untreated control group was killed at 6 days after injection. The four treated groups, killed at 90 days, received one of the following by intravenous injection: (a) 15 mg/kg of glucan on days 6, 34, and 62; (b) 100 mg/kg of the calcium chelate of DTPA, twice weekly for 12 wk, beginning on day 6; (c) both of these treatments; or (d) saline. Between days 6 and 90, the amount of plutonium in the liver decreased from 92.2 to 85.6% of the injected dose (ID) after saline, to 81.6% after glucan, to 77.8% after DTPA, and to 71.0% after both glucan and DTPA. The decrease to 71.0%, an approximately additive effect, was statistically significant. In dogs treated with either saline or glucan, the plutonium levels of the bones and the soft tissues other than the liver were higher than those in animals treated with DTPA. The 90-day excretion of plutonium in feces was low in all groups (3.3% ID, or less), while urinary plutonium was 3.5% ID after saline, 4.0% after glucan, 13.4% after DTPA, and 21.1% after glucan plus DTPA. These results confirm in dogs, as previously determined in mice, the action of glucan as an adjunct to DTPA in removal of polymeric plutonium from the liver.
Removal of Polymeric Plutonium from Dogs with DTPA and Glucan
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M. W. Rosenthal, A. Lindenbaum, D. W. Baxter, G. S. Kalesperis, E. S. Moretti, J. J. Russell; Removal of Polymeric Plutonium from Dogs with DTPA and Glucan. Radiat Res 1 August 1975; 63 (2): 253–261. doi: https://doi.org/10.2307/3574151
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