To study the influence of systems parameters on the radiosensitivity of cell populations, stationary chemostat cultures of diploid yeast with different dilution rates were γ-irradiated. Proliferation and budding kinetics were investigated and the doses necessary to eliminate the entire population determined as a function of dilution rate. It was found that this "killing" dose decreases with dilution rate in a linear manner. The radiosensitivity of the cells was shown to depend on the dilution rate which is presumably due to differing compositions of the population.
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Research Article| August 01 1975
Radiosensitivity of Continuous Cultures: Experiments with Diploid Yeast
Radiat Res (1975) 63 (2): 336–345.
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Jürgen Kiefer, Elisabeth Wagner; Radiosensitivity of Continuous Cultures: Experiments with Diploid Yeast. Radiat Res 1 August 1975; 63 (2): 336–345. doi: https://doi.org/10.2307/3574158
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