A mathematical model is proposed to explain the experimental observation of breaking survival curves obtained in ultrahigh dose rate studies. The model examines the kinetics of radiation-induced oxygen depletion in cells and of the decay and reactions of oxygen-dependent damage postulated to be involved in the oxygen effect for cells. A reaction scheme is assumed for radiochemical oxygen depletion where a set of radiation-induced species reacts with and binds dissolved oxygen molecules. The proposed theory of Howard-Flanders and Moore (11) on oxygen-dependent injury is also adopted to provide a description of the reaction and decay characteristics of the oxygen-dependent damage. A computerized examination of the time-dependent interaction of the above described processes indicates that calculated breaking survival curves are in good agreement with those observed experimentally.
Time Scale of Radiation-Induced Oxygen Depletion and Decay Kinetics of Oxygen-Dependent Damage in Cells Irradiated at Ultrahigh Dose Rates
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Ching Clifton Ling; Time Scale of Radiation-Induced Oxygen Depletion and Decay Kinetics of Oxygen-Dependent Damage in Cells Irradiated at Ultrahigh Dose Rates. Radiat Res 1 September 1975; 63 (3): 455–467. doi: https://doi.org/10.2307/3574097
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