The effects of3 H-thymidine on cell progression through the mitotic cycle and on cell population kinetics have been investigated. During continuous treatment there is a gradual inhibition of entry of cells from G2 into mitosis, while other stages of the cell cycle appear to be less radiosensitive. Hence there is an accumulation of cells in G2 while the proportions of cells in G1, S, and M decrease. Cells of the quiescent center are induced to synthesize DNA after inhibition of mitosis in the surrounding meristem. They do not serve to repopulate the meristem, however, since they then incorporate3 H-thymidine and are themselves arrested. It is suggested that the other slowly cycling cells of the meristem, in addition to those of the quiescent center, may also be induced to cycle more rapidly after delay in the fast-cycling population. These cells will also be arrested after a brief compensatory proliferative reaction. Thus the meristem is unable to recover from radiation damage during continuous treatment with3 H-thymidine.
Skip Nav Destination
Research Article| December 01 1975
Tritiated-Thymidine Induced Changes in Cell Population Kinetics in Root Meristems of Pisum sativum
Radiat Res (1975) 64 (3): 475–484.
- Views Icon Views
- Share Icon Share
- Search Site
D. G. Stetka, P. L. Webster; Tritiated-Thymidine Induced Changes in Cell Population Kinetics in Root Meristems of Pisum sativum. Radiat Res 1 December 1975; 64 (3): 475–484. doi: https://doi.org/10.2307/3574237
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner