Mitotically synchronized cultures of HeLa S-3 cells were subjected to the treatment of radiation (400 rad), hyperthermia (43°C), and a combination of both at different phases of the division cycle. The radioresistance was most pronounced in the mid G-1 and late S phases, while thermal resistance was greatest in the early G-1 phase and steadily decreased as cells entered the S phase. Cells in the late S and early G-2 phases were found to be most sensitive to hyperthermia. The sequential treatment of radiation immediately followed by hyperthermia resulted in an enhanced cell killing throughout the cell cycle with a marked synergism occurring in cells in the late S phase. The age-response function of the combined treatment was more similar to that of the thermal age response.
Skip Nav Destination
Research Article| May 01 1976
The Enhanced Killing of Irradiated HeLa Cells in Synchronous Culture by Hyperthermia
Radiat Res (1976) 66 (2): 337–345.
- Views Icon Views
- Share Icon Share
- Search Site
S. H. Kim, J. H. Kim, E. W. Hahn; The Enhanced Killing of Irradiated HeLa Cells in Synchronous Culture by Hyperthermia. Radiat Res 1 May 1976; 66 (2): 337–345. doi: https://doi.org/10.2307/3574401
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner