$3\text{-}[{}^{131}{\rm I},{}^{14}{\rm C}]\text{Iodotyrosine}$ was synthesized from$[{\rm U}\text{-}{}^{14}{\rm C}]\text{tyrosine}$ using the chloramine-T method of iodination. The131 I atom was allowed to decay in aqueous solvent containing electron scavengers and various additives. Reference systems were studied by synthesizing$3\text{-}[{}^{127}{\rm I},{}^{14}{\rm C}]\text{iodotyrosine}$ and adding131 I as iodide ion. These systems were used to correct for carbon-iodine bond hydrolysis. In the$3\text{-}[{}^{131}{\rm I},{}^{14}{\rm C}]\text{iodotyrosine}$ system the majority of the products could be explained by the formation of a second hydroxyl group in the aromatic ring followed by oxidation. However, the energy involved was sufficient to cause a carbon-carbon bond rupture on the side chain of the molecule following a small percentage of the decay events. The products formed from the$3\text{-}[{}^{127}{\rm I},{}^{14}{\rm C}]\text{iodotyrosine}$ system were only those resulting from hydroxyl addition and oxidation. The results are interpreted in terms of the excitation of the intermediates.

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