Dose-response curves for the reproductive capacity of crypt stem cells of murine colonic, jejunal, and gastric mucosae exposed in situ to multifractionated gamma ray exposures were analyzed and single-dose-survival curves of these cells were constructed. The following conclusions were drawn: (1) The single-dose-response curves bend downward over a dose range of approximately 200 to 1500 rad; (2) cell death seems to be due to nonrepairable damage at doses less than 250 rad for colon, and 220 rad for jejunum; (3) there are 21, 110, and 140 stem cells per crypt of gastric, colonic, and jejunal mucosa, respectively; and (4) jejunal stem cells are the most radiosensitive and gastric mucosal stem cells are the most resistant.
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Research Article| January 01 1977
Single-Dose-Response Curves of Murine Gastrointestinal Crypt Stem Cells
Kouji Masuda ;
H. Rodney Withers ;
Kathryn A. Mason ;
Radiat Res (1977) 69 (1): 65–75.
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Kouji Masuda, H. Rodney Withers, Kathryn A. Mason, Kuang Y. Chen; Single-Dose-Response Curves of Murine Gastrointestinal Crypt Stem Cells. Radiat Res 1 January 1977; 69 (1): 65–75. doi: https://doi.org/10.2307/3574517
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