The hypoxic character of the spermatogenic stem cells of the mouse testis was investigated by measuring the effect on radiosensitivity of treatment with the hypoxic cell radiosensitizer, Ro-07-0582 or hyperbaric oxygen (30 psi). The D0 values obtained were 181 (161-207) rad for irradiation alone, 140 (133-148) rad for irradiation after treatment with Ro-07-0582, and about 100 rad for irradiation in the presence of hyperbaric oxygen. Ro-07-0582 alone was slightly cytotoxic. The results demonstrate that mouse spermatogenic stem cells are radiosensitized by Ro-07-0582 or hyperbaric oxygen and are not as well oxygenated as other normal tissues.
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Research Article| March 01 1977
Radiosensitization of Mouse Spermatogenic Stem Cells by Ro-07-0582
Norio Suzuki ;
H. Rodney Withers ;
Radiat Res (1977) 69 (3): 598–601.
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Norio Suzuki, H. Rodney Withers, N. Hunter; Radiosensitization of Mouse Spermatogenic Stem Cells by Ro-07-0582. Radiat Res 1 March 1977; 69 (3): 598–601. doi: https://doi.org/10.2307/3574670
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