Influences of whole-body X irradiation on various aspects of creatine metabolism have been studied. Exposures to sublethal or lethal doses of X radiation results in excessive urinary excretion as well as higher accumulation of creatine in the skeletal muscle of X-irradiated rats. A sudden fall in CPK activity in muscle with a concomitant rise in serum suggests that changes in serum and tissue CPK activity are of an adaptive nature in rats exposed to sublethal doses of X radiation. In vitro studies on creatine synthesis shows that transaminidase and methyl transferase activities in kidneys and liver, respectively, are decreased on the 5th day in the X-irradiated rat. However, on the 8th day, the enzyme activities are restored to normal.
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Research Article| June 01 1977
Effects of Whole-Body X Irradiation on the Biogenesis of Creatine in the Rat
P. Thyagarajan ;
Radiat Res (1977) 70 (3): 519–529.
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P. Thyagarajan, U. K. Vakil, A. Sreenivasan; Effects of Whole-Body X Irradiation on the Biogenesis of Creatine in the Rat. Radiat Res 1 June 1977; 70 (3): 519–529. doi: https://doi.org/10.2307/3574642
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