The life cycle of synchronized S3 HeLa cells was examined during continuous irradiation at a dose rate of approximately 37 rad/hr and during multiple dose fractionation schedules of the same average dose rate (total dose ÷ overall time = average dose rate). For all regimes given at this dose rate the effects on the life cycle were similar. Cells progressed through G1 and S without appreciable delay and experienced a minimum G2 delay of about 10 hr. Cells eventually entered mitosis but virtually none were able to complete a successful division.
Dose-Rate Effects in Synchronous Mammalian Cells in Culture: II. A Comparison of the Life Cycle of HeLa Cells during Continuous Irradiation or Multiple-Dose Fractionation
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James B. Mitchell, Joel S. Bedford; Dose-Rate Effects in Synchronous Mammalian Cells in Culture: II. A Comparison of the Life Cycle of HeLa Cells during Continuous Irradiation or Multiple-Dose Fractionation. Radiat Res 1 September 1977; 71 (3): 547–560. doi: https://doi.org/10.2307/3574623
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