Recovery from potentially lethal damage (PLD) of cultured Chinese hamster cells (line CHO) after exposure to X rays and to α particles was investigated using both exponentially growing and plateau-phase cells (nutritionally induced stationary phase). The results indicated that there was no recovery from PLD after exposure to α particles from plutonium. Experiments were also conducted to determine if recovery phenomena were dependent on cell concentration. Recovery from PLD after X-ray exposure was not dependent on cell concentration. Cell-to-cell contact also does not seem to be an important factor in PLD recovery. The recovery curve shape after exposure to X rays, both for exponentially growing and plateau-phase CHO cells, remained identical; however, the magnitude of repair by plateau-phase cells was higher than by exponentially growing cells, indicating that cells in G1 may be primarily involved in PLD recovery.
Repair of Potentially Lethal Damage in Chinese Hamster Cells after X and α Irradiation
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M. R. Raju, J. P. Frank, E. Bain, T. T. Trujillo, R. A. Tobey; Repair of Potentially Lethal Damage in Chinese Hamster Cells after X and α Irradiation. Radiat Res 1 September 1977; 71 (3): 614–621. doi: https://doi.org/10.2307/3574628
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